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A number of biological and genetic characteristics distinguish low-count from high-count MBL.
Whereas low-count MBL rarely progresses to CLL, high-count MBL progresses to CLL requiring therapy at a rate of 1% to 2% per year.
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In subsamples of two additional cohorts, one in males and one in females, a positive association was seen between milk intake and both urine 8-iso-PGF2α (a biomarker of oxidative stress) and serum interleukin 6 (a main inflammatory biomarker).
A research librarian experienced in conducting literature searches for comparative effectiveness reviews searched in MEDLINE®, Pre MEDLINE, Embase®, the Cochrane Library, the Database of Abstracts of Reviews of Effects, the Health Technology Assessment Database, and the UK National Health Service Economic Evaluation database to capture literature published from January 1, 2007 through March 7, 2014.
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MBL can be categorized as either low count or high count based on whether the B-cell count is above or below 0.5 × 10/L.
Low-count MBL can be detected in ∼5% of adults over the age of 40 years when assessed using standard-sensitivity flow cytometry assays.